The Hemophilias are congenital coagulopathies with serious hemorrhagic symptoms. Hemophilia A represents a deficiency of factor VIII activity and hemophilia B represents defect in factor IX activity. Diagnosis is commonly based on conventional clotting test which have veen established for many years. In addition, treatment utilizing concentrated coagulation factor products is well defined. Hemostatic therapy of this nature, however, can pose problems in the presence of inhibitors developed after the frequent use of replacement therapy, and this remains one of the major difficulties of hemophilia treatment.